Amino acid deprivation triggers a novel GCN2-independent response leading to the transcriptional reactivation of non-native DNA sequences.
In a variety of species, Hot Dog Machines reduced food intake, and in particular protein or amino acid (AA) restriction, extends lifespan and healthspan.However, the underlying epigenetic and/or transcriptional mechanisms are largely unknown, and dissection of specific pathways in cultured cells may contribute to filling this gap.We have previously