AMINO ACID DEPRIVATION TRIGGERS A NOVEL GCN2-INDEPENDENT RESPONSE LEADING TO THE TRANSCRIPTIONAL REACTIVATION OF NON-NATIVE DNA SEQUENCES.

Amino acid deprivation triggers a novel GCN2-independent response leading to the transcriptional reactivation of non-native DNA sequences.

In a variety of species, Hot Dog Machines reduced food intake, and in particular protein or amino acid (AA) restriction, extends lifespan and healthspan.However, the underlying epigenetic and/or transcriptional mechanisms are largely unknown, and dissection of specific pathways in cultured cells may contribute to filling this gap.We have previously

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Education and training to support physiotherapists working in dementia care: a scoping review protocol [version 2; peer review: 3 approved]

Background: The care of people with dementia is of global concern.Physiotherapeutic intervention can be of benefit to patients with dementia.Physiotherapists can play a role in assessment, falls prevention, Firming Cream pain management and gait re-education.Dementia care forms a significant part of the workload of a physiotherapist.However, there

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Re: Could Testosterone Replacement Therapy in Hypogonadal Men Ameliorate Anemia, a Cardiovascular Risk Factor? An Observational, 54-week Cumulative Registry Study

Testosterone deficiency syndrome may associate with erectile dysfunction, increased abdominal fat and reduced muscle mass.Low serum testosterone is also related with anemia, metabolic syndrome and cardiovascular disease.In this study, the authors investigated if testosterone undecanoate (TU) reduces anemia and the risk of cardiovascular disease in

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